West Ham vs Chelsea
19th placed West Ham United host a Chelsea side undefeated in their last seven Premier League games.
The Hammers have only beaten Chelsea twice in their last 22 league matches, with Chelsea star Eden Hazard causing havoc for the West Ham defence on many an occasion.
Chelsea striker Alvaro Morata has kicked the third most goals in the Premier League this season with nine and will be a constant threat for the home side.
Prediction: West Ham 0 - 2 Chelsea
Burnley vs Watford
Burnley and Watford have the most points of the clubs outside the 'Big Six', making their Matchday 16 encounter an interesting prospect.
Watford haven't escaped a trip to Burnley with a win since 2004, drawing four and losing five in that time.
Midfielder Robbie Brady tore his patellar tendon in his left knee and will be missing for Burnley.
Prediction: Burnley 1 - 1 Watford
Crystal Palace vs Bournemouth
After a disastrous start to their campaign, Crystal Palace have managed to go unbeaten in their last four fixtures thanks to a stingy defence.
A win could lift Palace to equal points with 17th placed West Brom out of the relegation zone, a golden opportunity at home against a lower placed side to continue their solid form.
Prediction: Crystal Palace 1 - 0 Bournemouth
Huddersfield vs Brighton
Aaron Mooy's Huddersfield have gone through a rough patch of form after a promising start to the season, losing their last four Premier League games.
Brighton haven't registered a win in their last four contests either, resulting in a fixture where both sides will be desperate to break their drought.
This is the first match-up between the two clubs in English football's top tier.
Prediction: Huddersfield 2 - 1 Brighton
Swansea vs West Brom
Bottom-placed Swansea City have experienced a torrid run of form, losing six and drawing one of their last seven games, yet have an opportunity to turn it around at home against a West Brom side that hasn't won a Premier League game since Matchday 2.
Matt Phillips and Chris Brunt could make the trip to Wales to boost West Brom's chances of victory, where they've historically struggled to net points.
Prediction: Swansea 0 - West Brom 1
Tottenham vs Stoke
Tottenham will be desperate to record a win at home against Stoke City to put a stop to their four game win-less streak in the Premier League.
Stoke's recent history against Tottenham hasn't been pretty, losing their last three games to the Spurs with a scoreline of 4-0 on each occasion.
Stoke playmaker Xherdan Shaqiri has been directly involved in nine goals in his last 11 league appearances and will have to be at his attacking best to topple Tottenham.
Prediction: Tottenham 3 - 0 Stoke City
Newcastle vs Leicester
Newcastle face a stern test to turn around their six game win-less streak against an in-form Leicester side coming off back-to-back wins against Tottenham and Burnley.
However, history is against the Foxes, with Leicester having only won two of their last 17 league trips to Newcastle.
Striker Jamie Vardy is one goal off becoming the first Leicester player to slot 50 goals for the club.
Prediction: Newcastle 1 - 3 Leicester
Southampton vs Arsenal
Arsenal take a potentially tricky road trip to Southampton in Matchday 16 after falling to Manchester United 3-1 at home.
The Gunners have only come away from Southampton with all three points in the Premier League once in their last six matches.
Southampton haven't kept a clean sheet in their last six league games and will struggle to do so against the firepower of Alexandre Lacazette, Alexis Sanchez and Mesut Ozil.
Prediction: Southampton 0 - 2 Arsenal
Liverpool vs Everton
Liverpool enter the Merseyside Derby as red-hot favourites after a dominant run of form in the Premier League and in Europe.
Everton's league form has also been impressive in recent weeks however, winning their last two games in impressive fashion, yet a trip to Anfield could be a challenge too large for the Toffees.
Liverpool are undefeated against their cross-town rivals in all competitions since 2010 (7 wins and 7 draws).
Prediction: Liverpool 4 - 0 Everton
Manchester United vs Manchester City
The top-of-the-table Manchester Derby swiftly follows the Merseyside fixture, with the two Manchester clubs coming head to head on the back of lengthy winning runs.
A win for City could build an almost insurmountable gap between them and the rest of the competition, however a United win would close the gap to five points between them and City.
Romelu Lukaku will have to be at his absolute best to top the firepower City possess at the other end of the pitch, with the likes of Aguero, Jesus and Sterling sure to cause issues for United.
Prediction: Manchester City 2 - 0 Manchester United