Following the conclusion of the third-round ties on Thursday morning Australian time, the final 16 teams in the EFL Cup have been handed their fourth-round opponents.
Some marquee matches headline the next round of fixtures in the competition formerly known as the English League Cup, with none bigger than the Manchester derby.
United and City will face off for the second time this season, after City beat the Red Devils at Old Trafford in week four of the Premier League.
Other all Premier League matches include West Ham v Chelsea, Liverpool v Tottenham and Southampton v Sunderland.
The draw is listed in full below, with the home teams named first. The ties will take place on October 25 and 26.
FOURTH ROUND FIXTURES
West Ham v Chelsea
Manchester United v Manchester City
Arsenal v Reading
Liverpool v Tottenham
Bristol City v Hull City
Leeds United v Norwich
Newcastle United v Preston North End
Southampton v Sunderland