NORTHAMPTON, ENGLAND - SEPTEMBER 21: Jose Mourinho, Manager of Manchester United looks on during the EFL Cup Third Round match between Northampton Town and Manchester United at Sixfields on September 21, 2016 in Northampton, England. (Photo by Shaun Botterill/Getty Images)

Following the conclusion of the third-round ties on Thursday morning Australian time, the final 16 teams in the EFL Cup have been handed their fourth-round opponents.

Some marquee matches headline the next round of fixtures in the competition formerly known as the English League Cup, with none bigger than the Manchester derby.

United and City will face off for the second time this season, after City beat the Red Devils at Old Trafford in week four of the Premier League.

Other all Premier League matches include West Ham v Chelsea, Liverpool v Tottenham and Southampton v Sunderland.

The draw is listed in full below, with the home teams named first. The ties will take place on October 25 and 26.

FOURTH ROUND FIXTURES

West Ham v Chelsea

Manchester United v Manchester City

Arsenal v Reading

Liverpool v Tottenham

Bristol City v Hull City

Leeds United v Norwich

Newcastle United v Preston North End

Southampton v Sunderland